PANews reported on April 12 that, according to Jinshi News, US Vice President Vance held a press conference at the Serena Hotel in Islamabad, the capital of Pakistan. Vance stated that the US-Iran talks in Islamabad failed to reach an agreement, and significant differences remain between the two sides. Vance said that after approximately 21 hours of negotiations, the US and Iran still had not reached an agreement. The two sides had held several rounds of "substantive discussions," but ultimately failed to achieve any results.

He pointed out that the US had clearly stated its "red lines" and acceptable and unacceptable conditions, while Iran "chose not to accept these terms." Vance stated that the core reason for the failure of the US-Iran negotiations to reach an agreement was Iran's lack of a clear commitment to abandoning the development of nuclear weapons. Vance noted that the US demanded that Iran not only refrain from developing nuclear weapons currently, but also commit to not acquiring related capabilities and technologies in the long term, but "no such clear willingness has been seen yet." He emphasized that this goal was a core demand of US President Trump in the negotiations. Regarding the details of the negotiations, Vance stated that he would not disclose the specific content, but reiterated that the nuclear issue was one of the key points of contention.